Formatting - Your post need not be a circus. If you are not good with formatting, then stick to a theme that is light and descent in colors and the post layout. If you are good with trying new stuff then use that skill to better express through colors, fonts and layouts. Avoid colors that are dark and fonts that are overtly bright.
Image speak - A lot of bloggers tend to ignore this, but the images on your blog speak a lot for what you write. Use good quality images and make sure they express your written stuff in utmost simplicity yet precision.
Add your personality - If you are writing on a particular topic, there are a number of people who will be writing on the same topic. So you need to add that specialty to your blog to make it look different and to allow your readers to take away something that the others are not offering.