Never mess your blog with too much of Adsense ads. It gives a confusing look to the blog.
Add your personality - If you are writing on a particular topic, there are a number of people who will be writing on the same topic. So you need to add that specialty to your blog to make it look different and to allow your readers to take away something that the others are not offering.
Content is the king - In the blogging world so diverse and big, you need to establish yourself with a distinction. the only road to it is good, original and valuable content. Be creative, different and surprise your readers once in a while.